While Tom's very good at science, his brother is absolutely hopeless.
湯姆很擅長理科，而他的兄弟絕對是不可救藥。
This case is hopeless and he knows it.
這個案子毫無希望，這一點他是清楚的。
He's a hopeless case.
他是無可救藥了。
I'm hopeless at science.
我對理科一竅不通。
Our cat is hopeless at catching mice.
我們的貓絕對捉不到老鼠。
She felt lonely and hopeless.
她感到孤獨絕望。